GRANULATION LINE

Rapid Mixer Granulators (RMG) are widely used in pharmaceutical manufacturing process. It is used to mix pharmaceutical ingradients and make granules before next stage of operation.

Rapid Mixer Granulator consists of following:
•   Cylindrical mixing bowl
•   Three-bladed impeller
•   Auxiliary chopper
•   Gear box and drive for Agitator and Chopper
•   Mounting Platform
•   Control system with HMI

•   An impeller is employed to mix the dry powder and spread the granulating fluid.
•   The impeller of the high-shear mixer granulator normally rotates at a speed ranging from 100 to 500rpm.
•   The function of the chopper is to break down the wet mass to produce granules.
•   The rotation speed of the chopper ranges from 1000 to 3000rpm.

•   The Rapid Mixer Granulator performs dry mixing & wet granulating
•   Rapid Mixer Granulators (RMG) are primarily used for tablet manufacturing process which requires homogenous mixing, controlled granule size and at the same time assuring great reduction in processing time.

•   Needs small quantity of binder solution for granulation process
•   Achieves granulation within a short time
•   Needs short drying times
•   Predictable granulation endpoint
•   Higher densification and creating granules which are less friable
•   Generates reproducible less friable granules having a consistent particle size distribution
•   Reduces operators’ exposure to drug dust because of minimized generation of process dust

•   All parts are made of s.s 304/ s.s 316 grade
•   Granulation end-point control devices, which are used to detect the end point of the granulation process is optional
•   Provision for CIP / WIP

The Fluid Bed Processer & Coater is designed for Drying, Granulating and Coating of Powder.

Fluid Bed Processer & Coater consists of following:
•   Plenum chamber with air inlet.
•   Product container with perforated plate, sight glass, etc.
•   Filter housing with filter bags, filter ring, Air discharge, sight glass, etc.
•   Air handling unit.
•   Exhaust fan

•   The dryer runs in batch operation.
•   The Hot and dehumidified inlet air from AHU homogeneously flows through the special designed Conidure Sieve into the product vessel.
•   Moist powder in the Product Container is fluidized and kept in constant motion. This ensures an excellent heat transfer and high drying rate.
•   Integrated jet filters restrict flow of powder along with exhaust

The Fluid Bed Processor & Coater is key processing equipment used for
•   Drying
•   Granulating and
•   Coating of Powder

•   Drying, Granulating & Coating in one system thru various attachments.
•   Quick & easy filter replacement.
•   Easy cleaning.

A conical mill (or conical screen mill) is a machine used to reduce the size of material in a uniform manner.

Co-mill consists of following:
•   Feeding hopper
•   Impeller
•   Conical Mesh screen
•   Drive system
•   Frame & Base support – Fixed / Movable
•   Collection Chamber
•   Seals – Either made from silicone or PTFE

•   Materials are fed into the conical mill chamber through the in-feed chute. Usually there is gravity fed.
•   As the powder particles come into contact with the rotating impeller, it is broken up through shearing & attrition and flung against the perforated sieve.
•   Desired grain sizes pass through the perforation in the screen.
•   Increasing the speed of the impeller can result in smaller granules since it flattens the approach angle of particles to the screen’s surface.
•   Processed powder particles are collected in the receptacle, or vacuum conveyed to the next process equipment.

•   Reduction of particle sizes
•   Deagglomeration /De-clustering
•   Sieving / screening
•   Dispersion
•   Milling wet granules before drying

•   The sieves and the impeller can be changed easily and quickly.
•   Lesser residual losses.
•   Low noise level and low heat generation.
•   Gentle milling leading to a low fraction of fines.
•   Hygienic, since they are easy to clean.
•   Produce uniform particle sizes.
•   Have high-hourly capacities.
•   Less labor-intensive.
•   In-line vacuum conveying allows for high containment and protection of granules from damage as they are transferred from one process equipment to the next.

•   Easy to clean.
•   Vacuum Loading option.
•   The Bin charging Loading system can also be incorporated in it which is a dust free closed system for charging and discharging of powders or granules.
•   Material of construction S.S 316.
•   Standards Safety : No outside cables.

Multi Mill a standalone portable machine used for high-speed granulation, pulversing, mixing, shredding and chopping of wide range of wet and dry materials achieve desired size reduction.

Multi-mill consists of following:
•   Feeding hopper
•   Impeller
•   Cylindrical Mesh
•   Drive system
•   Frame & Base support – Fixed / Movable
•   Collection Chamber
•   Seals – Either made from silicone or PTFE.

•   Materials are fed into the cylindrical mill chamber through the feed Hopper. Usually there is gravity fed.
•   Powder particles come into contact with the rotating swing beaters having knife and impact edges. Granules / lumps are broken into small particle sizes by the mechanism of cutting, Pulverization, and hammering.
•   Desired grain sizes pass through the perforation in the screen.
•   Increasing the speed of the impeller can result in smaller granules.
•   Processed powder particles are collected in the receptacle.

Size reduction / Wet and dry granulation in:
•   Pharmaceutical, Chemical, Bulk Drug, Cosmetic, Dyestuffs and Food Processing Industries

•   Can be used for milled wet materials.
•   Easy for operational activity.
•   Variable speed options are also available.
•   Easy to dismantle and clean.
•   Required less space to install.
•   The sieves and the impeller can be changed easily and quickly.

•   All parts are made of s.s 304/ s.s 316 grade.
•   Machine is portable, as mounted on castor wheels.
•   All parts mainly product contact parts are easy to dismantle and clean.
•   Blades and scrapers are made of hard materials and plated with hard chrome.
•   Can be run for a long time continuously.
•   Varieties of perforated and knitted screens available to suit the product and application.
•   Use of cylindrical drum for high output.
•   Direction of the Blade rotation can be changed using a Reversing switch for Hammer or Knife operation.
•   Multiple combinations of Screens / Speeds / Number of Blades.
•   Additional perforated screen at the bottom of pulverizing chamber ensuring Higher Fineness and Controlled Size of Granules.
•   Built in Variable Frequency Drive for multiple speeds.

Oscilatory granulator is used for size reduction of product where by the product is forced to passed thru perforated sieve by oscillating rotor.

Oscilatory granulator consists of following:
•   Feeding hopper
•   Oscilating rotor
•   Housing for Oscillatory Rotor and perforated Cylinder
•   Drive arrangement
•   Movable Frame / Structure

•   Materials are fed into the cylindrical mill chamber through the feed Hopper.
•   Oscillatory rotor crushes the incoming mater and force it to pass thru perforated sieve.
•   Size of sieved depends on the sieve used for granulation.
•   Product is collected at the diacharge end.

•   Oscillating granulators are widely used in the pharmaceutical, chemical and nutritional industry for quick and efficient de-lumping and Particle reduction.
•   These robust machines are built for research, pilot scale and full production.

•   Very low fine particle fraction in the end product.
•   Low mechanical stress allows for the capability of processing heat sensitive products.

•   All parts are made of s.s 304/ s.s 316 grade.
•   The rotating sieve mill guarantees optimum sizing results plus excellent flow rates.
•   The 360-degree rotor movement ensures constant, uniform speed and force effect for gentle sizing of the product.
•   Easy installation, and maintenance and
•   Long service life.
•   All Stainless Steel in design.
•   Large non-marking castors.
•   Easy to clean.
•   Mirror polished side walls.
•   No cross contamination.
•   Low noise.

Comminuting mill is versatile machine used for size reduction milling, pulverization and dispersion of wet and dry products in pharmaceutical and chemical Industries.

Comminuting consists of following:
•   Inlet Hopper for charging product in to the mill
•   Milling Chamber with suitable size screen
•   Milling rotor with Cutting and Hammering ends
•   Discharge Chute
•   Drive Assembly with three speed step pulley

•   Materials are fed into the milling chamber through the feed Hopper.
•   Comminuting mill works on Cutting and Hammering mode.
•   Mill can run on variable speed.

Size reduction / Wet and dry granulation in:
•   pharmaceutical,

•   Robust machine.
•   Dual edge impeller for handling difficult product

•   In compliance with cGMP guidelines
•   Side discharge instead of center discharge
•   Option of fixed beaters assembly and swing beaters assembly
•   Available in Plain & Water Jacketed model
•   Beltless drive as an optional feature
•   Feed screw to maintain constant and uniform rate of feeding as an optional feature.
•   ACVFD for main and screw feeder motors as an optional feature.
•   Higher operator’s safety by interlocking belt guard, throat hopper and chamber assemble with the main motor
•   PU Castor Wheel for mobility with brakes
•   FLP construction (optional)

Automatic tablet coating machine is current solution for uniform and gentle coating of tablet in Pharma & Health care industries.

Auto Tablet coating system consists of following:
•   Solution feed system consisting of Solution tank, Feed Pump and necessary controls.
•   Cylindrical coating pan with provision for:
    (1) Loading and Unloading tablets.
    (2) Solution spray nozzles.
    (3) Air inlet and out let ports
•   PLC control system.
•   Air Handling unit to supply filtered, de-humidified, hot air.
•   Air exhaust system for discharging filtered / Clean Air.

•   Charging the Coating Pan with Tablets
•   Activating Air handling system
•   Initiating pan rotation
•   Initiating Solution spray system
•   Running the system for pre-defined time
•   Tablets unloading

Tablet coating in : Pharmaceutical

Can be used for milled wet materials.

•   In FLP Construction.
•   With solution tank, multi air pump, double skin AHU with Pre, Micro, HEPA filter. With steam and chilled coil.
•   With exhaust blower.
•   With wet scrubber assembly.
•   With Anti-Bearding Spray Gun for spraying system.
•   Steam Control Valve.
•   Chill Water Control Valve (De Humidification Valve).
•   Filter Maintenance Monitoring.
•   HEPA Filter Maintenance Monitoring.
•   Coating Pan Chamber Negative Pressure Monitoring.
•   Silencer at Exhaust.
•   Air Velocity Measurement.
•   Inlet Air Humidity Measurement.

Coating Pan is cost effective solution for coating of tablet in Pharma & Health care industries.

Coating Pan consists of following:
•   Feeding hopper
•   SS-316, Ellipsoidal pan with baffles inside mounted on suitable stand.
•   Drive arrangement consisting of suitable gear box and motor through.
•   Hot air blower with heater assembly and a flexible SS Pipe which goes into the pan for drying of the tables/ Material into the pan after coating.
•   Control panel, which consists of starter or VFD, Digital temp. Controller for controlling temperature.
•   Spraying system, consisting of suitable capacity pressurized vessel with spray gun mounted on the stand. Alternately a peristaltic pump is provided to transfer the liquid onto spray gun and then sprayed into the pan
•   Exhaust blower (Optional).
•   Wet scrubber (Optional) is also provided for neutralizing the exhaust fumes before entering into the open atmosphere.

•   Charging the Coating Pan with Tablets
•   Initiating pan rotation
•   Intiating Solution spray system
•   Running the system for pre-defined time
•   Running Drying Cycle
•   Tablets unloading

Tablet coating in : Pharmaceutical

•   In compliance with cGMP guidelines
•   All Contact parts SS 316 / SS 304 & Non- Contact parts SS 304
•   Conventional coating system for manual film coating and sugar coating
•   Easy interchange facility with different size of Pan
•   FLP construction can be provided.